ATPS-81SINGLE-AGENT TARGETING OF Eph RECEPTORS A2, A3, B2 AND INTERLUKIN-13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA
نویسندگان
چکیده
منابع مشابه
Simultaneous targeting of Eph receptors in glioblastoma
Eph tyrosine kinase receptors are frequently overexpressed and functional in many cancers, and they are attractive candidates for targeted therapy. Here, we analyzed the expression of Eph receptor A3, one of the most up-regulated factors in glioblastoma cells cultured under tumorsphere-forming conditions, together with EphA2 and EphB2 receptors. EphA3 was overexpressed in up to 60% of glioblast...
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Glioblastoma (GBM) is the most lethal primary brain tumor, and despite several refinements in its multimodal management, generally has very poor prognosis. Targeted immunotherapy is an emerging field of research that shows great promise in the treatment of GBM. One of the most extensively studied targets is the interleukin-13 receptor alpha chain variant 2 (IL13Rα2). Its selective expression on...
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In previous studies, we described a "counter-immunosurveillance" mechanism initiated by tumor-activated, interleukin-13 (IL-13)-producing natural killer T cells that signal Gr-1(+) cells to produce transforming growth factor-beta(1) (TGF-beta(1)), a cytokine that suppresses the activity of tumor-inhibiting cytolytic CD8(+) T cells. Here, we show that in two tumor models (the CT-26 metastatic co...
متن کاملA role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting.
Neurons of layers II and III of the entorhinal cortex constitute the major afferent connection of the hippocampus. The molecular mechanisms that target the entorhinal axons to specific layers in the hippocampus are not known. EphA5, a member of the Eph receptor family, which has been shown to play critical roles in axon guidance, is expressed in the entorhinal cortex, the origin of the perforan...
متن کاملEphrins and Eph Receptors
chemorepulsive factors. Integrin heterodimers are primary ECM receptors, which can exist in different functional states with respect to their affinity or avidity for ECM proteins (11, 35), and directed cell motility on ECM is promoted by targeted localization of high-affinity integrins at the leading edge of migrating cells (40). There is now mounting evidence that both chemoattractant and chem...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2015
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nov204.81